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ABER instrument

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ABER instrument
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Futura
Bioreactor 나 Fermentor 에서 실시간으로 LIVE cell의 Biomass를 측정할 수 있는 시스템 입니다.
Dead cell 이나 Debris, Bubble 등에 의한 오차를 줄일 수 있고, 각종 Risk 를 줄일 수 있어서 생산성을 크게 늘릴 수 있습니다
담당자 : 오상민

T) 02-576-6303
M) 010-4137-6303

이메일 : Victor@kyongshin.co.kr

제품소개

How the ABER biomass monitor works


Real time means real savings

Cells with intact plasma membranes in a fermenter can be considered to act as tiny capacitors under the influence of an electric field. The non-conducting nature of the plasma membrane allows a build up of charge. The resulting capacitance can be measured: it is dependent upon the cell type and is directly proportional to the membrane bound volume of these viable cells. 


A unique range of probes

Choose from a range of in situ steam sterilisable probes manufactured in robust materials that conform to FDA requirements & USP Class VI. The smooth, annular ring electrode arrangement provides a surface free of areas of entrapment and large EVEN electric field; ideal for many cell culture applications where cells will collect in any well or crevice. For production applications ABER offers a highly robust 25mm probe with flush electrodes- a design that is often used in cGMP bioreactors for cell culture. ABER can also provide probes that can be gamma irradiated for single use bioreactors. Option for a range of probes for single use bioreactors including single use, sterilisable and flow through cell.


Specification

Frequency Range:50KHz to 20MHz
Measuring Ranges:Capacitance: 0.0 to 400pF/cm
Conductivity: 1.0 to 40 mS/cm +/-0.1 mS/cm
(Higher ranges available with compatible probes)
Cell Concentration Range:Depends on cell sizes but typically:
Yeast (6 µm): 106 cells/ml to 1010 Cells/ml
Bacteria (1 µm): 109 cells/ml to 1013 Cells/ml
Animal Cell (12 µm): 105 cells/ml to 109 Cells/ml
Plant Cell (50 µm): 103 cells/ml to 107 Cells/ml
Resolution:Resolution: 0.1 pF/cm.
Approx:
Bacteria typically 0.1 g/L dry weight or 2x109 Cells/ml for E. Coli.
Yeast or Animal Cells 0.05g/L or 1 x105 Cells/ml
The relationship of these capacitance values to biomass levels depends upon the
cell type and line.
Accuracy:Typically bett er than ± 3% or ± 2% of the reading
Stability:Better than ± 0.2 pF/cm at constant temperature with standard conductivity solution of ~12 mS/cm
Linearity:Better than ± 1% over 100 pF/cm
Precision:Typically <±0.5 pF/cm, no filter active.
Power Supply:Natively 24V DC. This is typically supplied by an Aber Hub running on 110V AC to
240V AC mains.
Environmental:IP65 rated
Recommended ambient operating temperature range: 5°C to 40°C
  

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